NIRS Analysis of Ranitidine Hydrochloride Capsules

NIRS with application of chemometric method was applied to the analysis of Ranitidine hydrochloride capsules. Taking data of root of mean square error of cross-validation (RMSECV), root of mean square error of prediction (RMSEP) and determination coefficient as evaluation targets, models for qualitative and quantitative analysis of Ranitide hydrochloride capsules were established. By applying the multi-scattering correction (MSC) and 1st order derivation to the pretreatment of NIR spectra of the drug capsules, taking the number of principal component as 6, and the range of wave number between 9 090.92 cm-1 and 4 008.81 cm-1, number of wrong judgement of zero was attained in qualitative classification. In respect to quantitative analysis, the model was established under the following conditions: ① 1st order derivation was used in pretreatment of NIR spectra; ② range of wavenumber between 9 090.92 cm-1 and 4 008.81 cm-1 was selected, and ③ number of principal component of 5 was taken. The model was verified by analysis of samples taken from 13 different batches. Values of relative deviation between the determined values and the predicted values were found in the range of -4.20%-4.04%.